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Research themes
  1. Divergent total synthesis and structure-activity relationship of bioactive molecules in mushrooms

  2. Total synthesis and structure determination of marine-derived brominated acetogenins isolated from red algae

  3. Synthesis of structurally complex drug-lead molecules starting from abundant natural products

  4. Development of green organic synthesis method

Recent Research

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Skeletal Isomerization of Ergosterol-5,8-peroxide Leading to the Discovery of Unprecedented Ergostanes and Collective Syntheses of 5,6-Epoxysterols and (+)-Sarocladione

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One-Pot Conversion of Benzyl Alcohols to N-Protected Anilines and Alkyl Alcohols to Carbamoyl Azides

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Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of genus Hericium

Selected as a cover picture

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Potential Degradation of 4-Methyltetrahydropyran (4-MeTHP) under Oxidation Conditions

Selected as a cover picture

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Cyclopentyl methyl ether (CPME) and 4-methyltetrahydropyran (4-MeTHP): Basic chemical properties and applications as next generation reaction solvents

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Total Synthesis, Structure Revision and Neuroprotective Effect of Hericenones C–H and Their Derivatives

 

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Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (–)-Bromlaurenidificin

 

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4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent

   

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Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives

   

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Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside

   

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Grignard Reactions in Cyclopentyl Methyl Ether (CPME)

  

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Stereocontrolled Synthesis of a Possible Stereoisomer of Laurenidificin and a Formal Total Synthesis of (+)-Aplysiallene Featuring a Stereospecific Ring Contraction

  

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Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B and I, Hericenols BD, and Erinacerins A and B

  

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Evaluation of Cyclopentyl Methyl Ether (CPME) as a Solvent for Radical Reactions

 

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Total Synthesis and Structural Revision of Hericerin

 

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Stereocontrolled Synthesis of Substituted Bicyclic Ethers through Oxy-Favorskii Rearrangement. Total Synthesis of (±)-Communiol E

    

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Rapid Access to 6-Bromo-5,7-dihydroxyphthalide 5-Methyl Ether by a CuBr2-Mediated Multi-Step Reaction.

   

Acknowledgements

  • Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

  • Suzuki Kenzo Memorial Foundation for Medical Science Applied Research

  • Protein Research Foundation

  • Sumitomo Foundation

  • Shorai Science and Technology Foundation

  • (株)日本農薬

  • (株)クラレ

  • (株)福寿製薬

  • (株)日本ゼオン

  • (株)三菱化学技術研究センター及びエーピーアイコーポレーション

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