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Natural Product Chemistry Lab
Department of Applied Chemistry Faculty of Engineering, Osaka Institute of Technology
Research themes
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Divergent total synthesis and structure-activity relationship of bioactive molecules in mushrooms
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Total synthesis and structure determination of marine-derived brominated acetogenins isolated from red algae
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Synthesis of structurally complex drug-lead molecules starting from abundant natural products
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Development of green organic synthesis method
Recent Research
One-Pot Conversion of Benzyl Alcohols to N-Protected Anilines and Alkyl Alcohols to Carbamoyl Azides
Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of genus Hericium
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Potential Degradation of 4-Methyltetrahydropyran (4-MeTHP) under Oxidation Conditions
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Cyclopentyl methyl ether (CPME) and 4-methyltetrahydropyran (4-MeTHP): Basic chemical properties and applications as next generation reaction solvents
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Total Synthesis, Structure Revision and Neuroprotective Effect of Hericenones C-H and Their Derivatives
Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (−)-Bromlaurenidificin
4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent
Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives
Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside
Stereocontrolled Synthesis of a Possible Stereoisomer of Laurenidificin and a Formal Total Synthesis of (+)-Aplysiallene Featuring a Stereospecific Ring Contraction
Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B, and I, Hericenols B-D, and Erinacerins A and B
Evaluation of cyclopentyl methyl ether (CPME) as a solvent for radical reactions
Stereocontrolled synthesis of substituted bicyclic ethers through oxy-Favorskii rearrangement: Total synthesis of communiol E
Total synthesis of hericene A featuring a CuBr2-mediated one-pot multi-step reaction
Acknowledgements
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一般財団法人 蛋白質研究奨励会
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公益財団法人 住友財団
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(株)日本農薬
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(株)クラレ
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(株)福寿製薬
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(株)日本ゼオン
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(株)三菱化学技術研究センター及びエーピーアイコーポレーション
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