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Total synthesis and structural revision of hericerin

 

Total synthesis and structural revision of hericerin

Hericerin, isolated from the mushroom Hericium erinaceum, shows inhibitory activity against pine pollen germination and tea pollen growth, and therefore is expected to be useful as a research tool for agrochemical discovery. We achieved the first total synthesis of hericerin starting from the originally prepared phthalide intermediate. Our findings reveal that the actual structure of hericerin is the carbonyl regioisomer of the original compound.

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