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Stereocontrolled synthesis of substituted bicyclic ethers through oxy-Favorskii rearrangement: Total synthesis of communiol E

    

Stereocontrolled synthesis of substituted bicyclic ethers through oxy-Favorskii rearrangement: Total synthesis of communiol E

A convenient, stereocontrolled route to branched cis-fused bicyclic ethers through halolactonization, α-bromination, and oxy-Favorskii rearrangement is developed. The total synthesis of communiol E, a bicyclic polyketide isolated from Podospora communis, was achieved based on this method.

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