Natural Product Chemistry Lab
Department of Applied Chemistry Faculty of Engineering, Osaka Institute of Technology
Original Papers
If you would like to see the original paper, please request it from ResearchGate.
Bioinspired Aerobic Oxidation to Functionalize the CD Ring of the Steroid Framework: Synthesis and Stereochemical Assignments of Gargalol C and Related Oxysterols
Togo, H.; Kanda, Y.; Kobayashi, S.*
Bioinspired Chemical Transformations of Grayanotoxin III to Kalmanol, seco-Rhodomollone, Rhodomolleins XXIII and XXIV
Tsuruyama, T.; Togo, H.; Kobayashi, S.*
Uncovering hericenones from the fruiting bodies of Hericium erinaceus through interdisciplinary collaboration
Wang, J.; Wu, J.; Yamaguchi, R.; Nagai, K.; Liu, C.; Choi, J.-H.; Hirai, H.; Xie, X.;* Kobayashi, S.;* Kawagishi, H.*
Skeletal Isomerization of Ergosterol-5,8-peroxide Leading to the Discovery of Unprecedented Ergostanes and Collective Syntheses of 5,6-Epoxysterols and (+)-Sarocladione
Nagayasu, S.; Togo, H.; Nagai, K.; Kobayashi, S.*
One-Pot Conversion of Benzyl Alcohols to N-Protected Anilines and Alkyl Alcohols to Carbamoyl Azides
Kobayashi, S.* Yamaguchi, R.; Yamamoto, F.; Komori, J.; Sakamoto, H. Kasashima, T.; Adriaenssens, L.; Lear, M. J.*
Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of genus Hericium
Kobayashi, S.*
(Selected for the cover graphic.)(Open Access)
Potential Degradation of 4-Methyltetrahydropyran (4-MeTHP) under Oxidation Conditions
Kobayashi, S.;* Tamura, T.
(Selected as a Cover Feature)(Open Access)
Cyclopentyl methyl ether (CPME) and 4-methyltetrahydropyran (4-MeTHP): Basic chemical properties and applications as next generation reaction solvents
Kobayashi, S.*
J. Synth. Org. Chem. Jpn 2021 , 79 (6), 547-557. (in Japanese)
Total Synthesis, Structure Revision and Neuroprotective Effect of Hericenones C–H and Their Derivatives
Kobayashi, S.;* Tamura, T.; Koshishiba, M.; Yasumoto, T.; Shimizu, S.; Kintaka, T.; Nagai, K.
Stereocontrolled Total Synthesis of (+)-Isolaurenidificin and (–)-Bromlaurenidificin
Kobayashi, S.;* Hori, Y.; Yoneyama, R.; Tamura, T.; Masuyama, A.
4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent
Kobayashi, S.;* Tamura, T.; Yoshimoto, Y.; Kawakami, T.; Masuyama, A.
(Selected for a special collection celebrating 100th Annual Meeting of CSJ)(Open Access)
Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives
Kobayashi, S.;* Hamada, Y.; Yasumoto, T.; Hashino, Y.; Masuyama, A.; Nagai, K.*
Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside
Kobayashi, S.;* Shibukawa, K.; Hamada, Y.; Kuruma, T.; Kawabata, A.; Masuyama, A.
Grignard Reactions in Cyclopentyl Methyl Ether (CPME)
Kobayashi, S.;* Shibukawa, K.; Miyaguchi, Y.; Masuyama, A.
(Most Accessed 07/2020 to 06/2021)(Open Access)
Stereocontrolled Synthesis of a Possible Stereoisomer of Laurenidificin and a Formal Total Synthesis of (+)-Aplysiallene Featuring a Stereospecific Ring Contraction
Kobayashi, S.;* Yokoi, T.; Inoue, T.; Hori, Y.; Saka, T.; Shimomura, T.; Masuyama, A.
Divergent Total Synthesis of Bioactive Molecules Derived from the Fruiting Bodies of Hericium erinaceum
Kobayashi, S.*
J. Synth. Org. Chem. Jpn 2015 , 73 (2), 131-139. (in Japanese)
Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B and I, Hericenols B−D, and Erinacerins A and B
Kobayashi, S.;* Tamanoi, H.; Hasegawa, Y.; Segawa, Y.; Masuyama, A.
Evaluation of Cyclopentyl Methyl Ether (CPME) as a Solvent for Radical Reactions
Kobayashi, S.;* Kuroda, H.; Ohtsuka, Y.; Kashihara, T.; Masuyama, A.; Watanabe, K.
Total Synthesis and Structural Revision of Hericerin
Kobayashi, S.;* Inoue, T.; Ando, A.; Tamanoi, H.; Ryu, I.; Masuyama, A.
Rapid Access to 6-Bromo-5,7-dihydroxyphthalide 5-Methyl Ether by a CuBr2-Mediated Multi-Step Reaction. Concise Total Syntheses of Hericenone J and 5'-Deoxohericenone C (Hericene A)
Kobayashi, S.;* Ando, A.; Kuroda, H.; Ejima, S.; Masuyama, A.; Ryu, I.
Stereocontrolled Synthesis of Substituted Bicyclic Ethers through Oxy-Favorskii Rearrangement. Total Synthesis of (±)-Communiol E
Kobayashi, S.;* Kinoshita, T.; Kawamoto, T.; Wada, M.; Kuroda, H.; Masuyama, A.; Ryu, I.
(Featured in Synfacts 2011, 11, 1160.)
Black Light Induced Radical Hydroxymethylation of Alkyl Iodides with Atmospheric CO in the Presence of Tetrabutylammonium Borohydride
Kobayashi, S.; Kawamoto, T.; Uehara, S.; Fukuyama, T.; Ryu, I.*
Novel Radical Cyclization Method Accompanied by Elimination of Hydrazyl Radical
Kobayashi, S.; Hirao, H.; Kawauchi, T.; Ryu, I.*
Organocatalytic Enantioselective Synthesis of Nitrogen-Substituted Dihydropyran-2-one, A Key Synthetic Intermediate of 1β-Methylcarbapenems
Kobayashi, S.;* Uehara, H.; Kinoshita, T.; Sudo, T.; Ryu, I.
Enantioselective Synthesis of the Fully Functionalized ABC ring of Zoanthenol
Sugano, N.; Koizumi, Y.; Hirai, G.; Oguri, H.; Kobayashi, S.; Yamashita, S.; Hirama, M.*
Construction of the CDE-Ring Framework of Erinacine E through Pummerer-type Cyclization
Kobayashi, S.;* Ishii, A.; Toyota, M.
Synthesis of trans-Fused Tetrahydrooxepins: Stereoselective Allylation of Sulfur or Fluoro-substituted Tetrahydrooxepins
Kobayashi, S.;* Hori, M.; Hirama, M.




























